CFR > Title 21 - Food and Drugs > CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES > SUBCHAPTER E—ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS (parts 500 to 590) > PART 558—NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS > SUBPART B—Specific New Animal Drugs for Use in Animal Feeds (§558.55 to §558.680) > 558.615—Thiabendazole.

558.615—Thiabendazole.

(a) Approvals. Dry Type A medicated articles: 22, 44.1, 66.1, and 88.2 percent to 050604 in § 510.600(c) of this chapter. The 66.1 percent Type A is solely for the manufacture of cane molasses liquid Type B feed which is mixed in dry feeds. The 88.2 percent Type A is used solely for the manufacture of an aqueous slurry for adding to a Type C dry cattle feed.
(b) Special considerations. Do not use in Type B or Type C medicated feed containing bentonite.
(c) Related tolerances. See § 556.730 of this chapter.
(d) Conditions of use. It is used in feed for animals as follows:
(1) Cattle— (i) Amount. 3 grams per 100 lb. body weight.
(a) Indications for use. Control of infections of gastrointestinal roundworms (Trichostrongylus spp., Haemonchus spp., Ostertagia spp., Nematodirus spp., Oesophagostomum radiatum ).
(b) Limitations. Use 3 grams per 100 lb. body weight at a single dose; may repeat once in 2 to 3 weeks; do not treat animals within 3 days of slaughter; milk taken from treated animals within 96 hours (8 milkings) after the latest treatment must not be used for food.
(ii) Amount. 5 grams per 100 lb. body weight.
(a) Indications for use. Control of severe infections of gastrointestinal roundworms (Trichostrongylus spp., Haemonchus spp., Ostertagia spp., Nematodirus spp., Oesophagostomum radiatum ); control of infections of Cooperia spp.
(b) Limitations. 5 grams per 100 lb. body weight at a single dose or divided into 3 equal doses, administered 1 dose each day, on succeeding days; may repeat once in 2 to 3 weeks; do not treat animals within 3 days of slaughter; milk taken from treated animals within 96 hours (8 milkings) after the latest treatment must not be used for food.
(2) Goats— (i) Amount. 3 grams per 100 lb. body weight.
(ii) Indications for use. Control of severe infections of gastrointestinal roundworms (Trichostrongylus spp., Haemonchus spp., Ostertagia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Strongyloides spp., Chabertia spp., and Oesophagostomum spp. ).
(iii) Limitations. 3 grams per 100 lb. body weight at a single dose; do not treat animals within 30 days of slaughter; milk taken from treated animals within 96 hours (8 milkings) after the latest treatment must not be used for food.
(3) Sheep and goats— (i) Amount. 2 grams per 100 lb. body weight.
(ii) Indications for use. Control of infections of gastrointestinal roundworms (Trichostrongylus spp., Haemonchus spp., Ostertagia spp., Cooperia spp.; Nematodirus spp., Bunostomum spp., Strongyloides spp., Chabertia spp., and Oesophagostomum spp. ); also active against ova and larvae passed by sheep from 3 hours to 3 days after the feed is consumed (good activity against ova and larvae of T. colubriformis and axei, Ostertagia spp., Nematodirus spp., Strongyloides spp.; less effective against those of Haemonchus contortus and Oesophagostomum spp. ).
(iii) Limitations. Use 2 grams per 100 lb. body weight at a single dose; do not treat animals within 30 days of slaughter; milk taken from treated animals within 96 hours (8 milkings) after the latest treatment must not be used for food.
(4) For swine— (i) Amount. 45.4-908 grams per ton (0.005-0.1 percent).
(ii) Indications for use. Aid in the prevention of infections of large roundworms (genus Ascaris ).
(iii) Limitations. Administer continuously feed containing 0.05-0.1 percent thiabendazole per ton for 2 weeks followed by feed containing 0.005-0.02 percent thiabendazole per ton for 8-14 weeks; do not treat animals within 30 days of slaughter.
(5) Pheasants— (i) Amount. 454 grams per ton (0.05 percent) continuously for 2 weeks (14 days).
(ii) Indications for use. For the treatment of gapeworms (Syngamus trachea) in pheasants.
(iii) Limitations. Do not use treated pheasants for food for 21 days after last day of treatment. Fertility, hatchability, and other reproductive data are not available on use in breeding animals.

Code of Federal Regulations

[40 FR 13959, Mar. 27, 1975, as amended at 47 FR 49641, Nov. 2, 1982; 49 FR 29958, July 25, 1984; 51 FR 7400, Mar. 3, 1986; 52 FR 2686, Jan. 26, 1987; 62 FR 63271, Nov. 28, 1997]