CFR > Title 21 - Food and Drugs > CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES > SUBCHAPTER E—ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS (parts 500 to 590) > PART 558—NEW ANIMAL DRUGS FOR USE IN ANIMAL FEEDS > SUBPART B—Specific New Animal Drugs for Use in Animal Feeds (§558.55 to §558.680) > 558.415—Novobiocin.

558.415—Novobiocin.

(a) Approvals. Type A medicated articles: 25 grams of activity per pound to 000009 in § 510.600(c) of this chapter. Type B medicated feeds: 17.5 grams per pound to 000009 in § 510.600(c) of this chapter.
(b) Related tolerances. See § 556.460 of this chapter.
(c) Conditions of use. It is used in animal feeds as follows:
(1) Chickens— (i) Amount. Novobiocin, 6-7 mgs. per lb. body weight per day.
(a) Indications for use. Aid in the treatment of breast blisters associated with staphylococcal infections susceptible to novobiocin.
(b) Limitations. Administer, as sole ration, feed which contains not less than 200 grams of novobiocin activity per ton of feed; not for laying chickens; feed 5 to 7 days; withdraw 4 days before slaughter.
(ii) Amount. Novobiocin, 10-14 mgs. per lb. body weight per day.
(a) Indications for use. Treatment of staphylococcal synovitis and generalized staphylococcal infections susceptible to novobiocin.
(b) Limitations. Administer, as sole ration, feed which contains not less than 350 grams of novobiocin activity per ton of feed; not for laying chickens; feed 5 to 7 days; withdraw 4 days before slaughter.
(2) Turkeys— (i) Amount. Novobiocin, 4-5 mgs. per lb. body weight per day.
(a) Indications for use. Aid in the treatment of breast blisters associated with staphylococcal infections susceptible to novobiocin.
(b) Limitations. Administer, as sole ration, feed which contains not less than 200 grams of novobiocin activity per ton of feed; not for laying turkeys; feed 5 to 7 days; withdraw 4 days before slaughter.
(ii) Amount. Novobiocin, 5-8 mgs. per lb. body weight per day.
(a) Indications for use. Aid in the control of recurring outbreaks of fowl cholera caused by strains of Pasteurella multocida susceptible to novobiocin following initial treatment with 7-8 mgs. per pound body weight per day.
(b) Limitations. Administer, as sole ration, feed which contains not less than 200 grams of novobiocin activity per ton of feed; feed 5 to 7 days; not for laying turkeys; withdraw 4 days before slaughter.
(iii) Amount. Novobiocin, 7-8 mgs. per lb. body weight per day.
(a) Indications for use. Treatment of staphylococcal synovitis and generalized staphylococcal infection susceptible to novobiocin; treatment of acute outbreaks of fowl cholera caused by strains of Pasteurella multocida susceptible to novobiocin.
(b) Limitations. Administer, as sole ration, feed which contains not less than 350 grams of novobiocin activity per ton of feed; feed 5 to 7 days; not for laying turkeys; withdraw 4 days before slaughter.
(3) Mink— (i) Amount. 20 mgs. per lb. body weight per day.
(ii) Indications for use. For treatment of generalized infections, abscesses, or urinary infections caused by staphylococcal or other novobiocin sensitive organisms.
(iii) Limitations. Administer, as sole ration, feed which contains not less than 200 grams of novobiocin activity per ton of feed; feed for 7 days.
(4) Ducks— (i) Amount. Novobiocin, 350 grams per ton.
(ii) Indications for use. Control of infectious serositis and fowl cholera in ducks caused by Pasteurella anatipestifer and P. multocida, susceptible to novobiocin.
(iii) Limitations. Administer, as sole ration, for 5 to 7 days, continue medication for 14 days if necessary, repeat if reinfection occurs; discontinue use at least 3 days before slaughter; not for use in laying ducks.

Code of Federal Regulations

[40 FR 13959, Mar. 27, 1975, as amended at 45 FR 42263, June 24, 1980; 51 FR 7399, Mar. 3, 1986; 52 FR 36402, Sept. 29, 1987]