CFR > Title 21 - Food and Drugs > CHAPTER I—FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES > SUBCHAPTER E—ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS (parts 500 to 590) > PART 556—TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD > SUBPART B—Specific Tolerances for Residues of New Animal Drugs (§556.34 to §556.770) > 556.113—Ceftiofur.

556.113—Ceftiofur.

(a) Acceptable daily intake and acceptable single-dose intake— (1) Acceptable daily intake (ADI). The ADI for total residues of ceftiofur is 30 micrograms per kilogram of body weight per day.
(2) Acceptable single-dose intake (ASDI). The ASDI total residues of ceftiofur is 0.830 milligrams per kilogram of body weight. The ASDI is the amount of total residues of ceftiofur that may safely be consumed in a single meal. The ASDI is used to derive the tolerance for residues of desfuroylceftiofur at the injection site.
(b) Tolerances— (1) Poultry, and sheep. A tolerance for residues of ceftiofur in edible tissue is not required.
(2) Swine. The tolerances for desfuroylceftiofur (marker residue) are:
(i) Kidney (target tissue). 0.25 parts per million (ppm).
(ii) Liver. 3 ppm.
(iii) Muscle. 2 ppm.
(3) Cattle. The tolerances for desfuroylceftiofur (marker residue) are:
(i) Kidney (target tissue). 0.4 ppm.
(ii) Liver. 2 ppm.
(iii) Muscle. 1 ppm.
(iv) Milk. 0.1 ppm.

Code of Federal Regulations

[63 FR 53579, Oct. 6, 1998, as amended at 68 FR 60296, Oct. 22, 2003; 69 FR 43892, July 23, 2004; 71 FR 39546, July 13, 2006]