520.763a—Dithiazanine iodide tablets.
(a) Chemical name.
3-Ethyl-2-[5-(3-ethyl - 2 - benzothiazolinylidene) - 1,3 - pentadienyl]-benzothiazolium iodide.
(b) Specifications.
Dithiazanine iodide tablets contain 10 milligrams, 50 milligrams, 100 milligrams, or 200 milligrams of dithiazanine iodide in each tablet.
(d) Conditions of use.
(1)
The tablets are administered orally to dogs immediately after feeding using the following dosage schedule for various parasite infestations:
| Milligrams per pound of body weight | Length of treatment—days | |
|---|---|---|
| Large roundworms (Toxocara canis, Toxascaris leonina) | 10 | 3-5 |
| Hookworms (Ancylostoma caninum, Uncinaria stenocephala) | 10 | 7 |
| Whipworms (Trichuris vulpis) | 10 | |
| Strongyloides (Strongyloides canis, Strongyloides stercoralis) | 10 | 10-12 |
| Heartworm microfilariae (Dirofilaria immitus) | 3-5 | 7-10 |
| Note: Treatment with dithiazanine iodide for heartworm microfilariae should follow 6 weeks after therapy for adult worms. | ||
(2)
The drug is contraindicated in animals sensitive to dithiazanine iodide and should be used cautiously, if at all, in dogs with reduced renal function.
(e)
Use for treating dogs for large roundworms, hookworms, whipworms, and strongyloides as provided for in this section has been NAS/NRC reviewed and deemed effective. Applications for these uses need not include effectiveness data as specified by § 514.111 of this chapter, but may require bioequivalency and safety information.