520.540b—Dexamethasone tablets and boluses.
(3) Conditions of use.
(i)
Dexamethasone bolus is indicated in cases where cattle and horses require additional steroid therapy following its parenteral administration. The drug may be used as supportive therapy for management of inflammatory conditions such as acute arthritic lamenesses, and for various stress conditions where corticosteroids are required while the animal is being treated for a specific condition.
(ii)
Administered orally, 5 to 10 milligrams for the first day, then 5 milligrams per day as required.
(iii)
Do not use in viral infections during the viremic stage. With bacterial infections, appropriate antibacterial therapy should be used.
(iv)
Do not use in animals with chronic nephritis and hypercorticalism (cushingoid syndrome), except for emergency therapy.
(v)
Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
(vi)
Federal law restricts this drug to use by or on the order of a licensed veterinarian. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal.
(3) Conditions of use—
(i) Amount.
Dogs: Administer orally at 0.25 to 1.25 milligrams per day for up to 7 days. Cats: 0.125 to 0.5 milligram per day for up to 7 days. 1
Code of Federal Regulations
Footnote(s): 1 These conditions are NAS/NRC reviewed and deemed effective. Applications for these uses need not include effectiveness data as specified by § 514.111 of this chapter.
(iii) Limitations.
(a) Clinical and experimental data have demonstrated that corticosteriods administered orally or by injection to animals may induce the first stage of parturition when administered during the last trimester of pregnancy; and they may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
(b) Do not use in viral infections. Anti-inflammatory action of corticosteroids may mask signs of infections. Do not use in animals with tuberculosis, chronic nephritis, cushingoid syndrome, or peptic ulcers, except for emergency therapy. 1
(c) Federal law restricts this drug to use by or on the order of a licensed veterinarian. 1