175.105—Adhesives.

(a) Adhesives may be safely used as components of articles intended for use in packaging, transporting, or holding food in accordance with the following prescribed conditions:
(1) The adhesive is prepared from one or more of the optional substances named in paragraph (c) of this section, subject to any prescribed limitations.
(2) The adhesive is either separated from the food by a functional barrier or used subject to the following additional limitations:
(i) In dry foods. The quantity of adhesive that contacts packaged dry food shall not exceed the limits of good manufacturing practice.
(ii) In fatty and aqueous foods. (a) The quantity of adhesive that contacts packaged fatty and aqueous foods shall not exceed the trace amount at seams and at the edge exposure between packaging laminates that may occur within the limits of good manufacturing practice.
(b) Under normal conditions of use the packaging seams or laminates will remain firmly bonded without visible separation.
(b) To assure safe usage of adhesives, the label of the finished adhesive container shall bear the statement “food-packaging adhesive”.
(c) Subject to any limitation prescribed in this section and in any other regulation promulgated under section 409 of the Act which prescribes safe conditions of use for substances that may be employed as constituents of adhesives, the optional substances used in the formulation of adhesives may include the following:
(1) Substances generally recognized as safe for use in food or food packaging.
(2) Substances permitted for use in adhesives by prior sanction or approval and employed under the specific conditions of use prescribed by such sanction or approval.
(3) Flavoring substances permitted for use in food by regulations in this part, provided that such flavoring substances are volatilized from the adhesives during the packaging fabrication process.
(4) Color additives approved for use in food.
(5) Substances permitted for use in adhesives by other regulations in this subchapter and substances named in this subparagraph: Provided, however, That any substance named in this paragraph and covered by a specific regulation in this subchapter, must meet any specifications in such regulation.
Substances Limitations
Abietic acid
Acetone
Acetone-formaldehyde condensate (CAS Reg. No. 25619-09-4)
Acetone-urea-formaldehyde resin
N-Acetyl ethanolamine
Acetyl tributyl citrate
Acetyl triethyl citrate
2-Acrylamido-2-methyl-propanesulfonic acid, homopolymer, sodium salt (CAS Reg. No. 35641-59-9)
Albumin, blood
(2-Alkenyl) succinic anhydrides in which the alkenyl groups are derived from olefins which contain not less than 78 percent C30 and higher groups (CAS Reg. No. 70983-55-0)
4-[2-[2-2-(Alkoxy (C12-C15) ethoxy) ethoxy]ethyl] disodium sulfosuccinate
1-Alkyl (C6-C18) amino-3-amino-propane monoacetate
Alkylated (C4 and/or C8) phenols
Alkyl (C7-C12) benzene
Alkyl (C10-C20) dimethylbenzyl ammonium chloride
n-Alkyl(C12, C14, C16, or C18) dimethyl (ethylbenzyl) ammonium cyclohexylsulfamate For use as preservative only.
Alkyl ketene dimers as described in § 176.120 of this chapter
Alkyl (C7-C12) naphthalene
alpha Olefin sulfonate [alkyl group is in the range of C10-C18 with not less than 50 percent C14-C16], ammonium, calcium, magnesium, potassium, and sodium salts
2-[(2-aminoethyl)amino]ethanol (CAS Reg. No. 111-41-1)
3-Aminopropanediol For use only in the preparation of polyurethane resins.
Aluminum
Aluminum acetate
Aluminum di(2-ethylhexoate)
Aluminum potassium silicate
N-β-Aminoethyl-gamma-aminopropyl trimethoxysilane
3-(Aminomethyl)-3,5,5-trimethylcyclohexylamine
Aminomethylpropanol
Ammonium benzoate For use as preservative only.
Ammonium bifluoride For use only as bonding agent for aluminum foil, stabilizer or preservative. Total fluoride from all sources not to exceed 1 percent by weight of the finished adhesive.
Ammonium borate
Ammonium citrate
Ammonium persulfate
Ammonium polyacrylate
Ammonium potassium hydrogen phosphate
Ammonium silico-fluoride For use only as bonding agent for aluminum foil, stabilizer, or preservative. Total fluoride from all sources not to exceed 1 percent by weight of the finished adhesive.
Ammonium sulfamate
Ammonium thiocyanate
Ammonium thiosulfate
Amyl acetate
Anhydroenneaheptitol
Animal glue as described in § 178.3120 of this chapter
2-Anthraquinone sulfonic acid, sodium salt For use only as polymerization-control agent.
Antimony oxide
Asbestos
Asphalt, paraffinic and naphthenic
Azelaic acid
Azo-bis-isobutyronitrile
Balata rubber
Barium acetate
Barium peroxide
Barium sulfate
Bentonite
Benzene (benzol)
1,4-Benzenedicarboxylic acid, bis[2-(1,1-dimethylethyl)-6-[[3-(1,1-dimethylethyl)-2-hydroxy-5-methylphenyl]methyl]-4-methyl-phenyl]ester (CAS Reg. No. 57569-40-1) For use as a stabilizer.
1,2-Benzisothiazolin-3-one (CAS Registry No. 2634-33-5) For use as preservative only.
Code of Federal Regulations 158
Benzothiazyldisulfide
p-Benzoxyphenol For use as preservative only.
Benzoyl peroxide
Benzyl alcohol
Benzyl benzoate
Benzyl bromoacetate For use as preservative only.
p-Benzyloxyphenol Do.
BHA (butylated hydroxyanisole)
BHT (butylated hydroxytoluene)
Bicyclo[2.2.1]hept-2-ene-6-methyl acrylate
2-Biphenyl diphenyl phosphate
Bis(benzoate-O)(2-propanolato)aluminum (CAS Reg. No. 105442-85-1) For use only as a reactant in the preparation of polyester resins.
1,2-Bis(3,5-di-tert-butyl-4-hydroxyhydrocinnamoyl)hy-drazine (CAS Reg. No. 32687-78-8) For use at a level not to exceed 2 percent by weight of the adhesive.
1,3-Bis(2-benzothiazolylmercaptomethyl) urea
4,4′-Bis(α,α-dimethylbenzyl)diphenylamine
2,6-Bis(1,1-dimethylethyl)-4-(1-methylpropyl)phenol (CAS Reg. No. 17540-75-9) For use as an antioxidant and/or stabilizer only.
2,6-Bis (1-methylheptadecyl)-p-cresol
4-[[4, 6-Bis(octylthio)6-Bis(octylthio)6-Bis(octylthio)-s-triazin-2-yl]amino]-2,6-di-tert-butylphenol (CAS Reg. No. 991-84-4)
Bis(tri-n-butyltin) oxide For use as preservative only.
Bis(trichloromethyl)sulfone C.A. Registry No. 3064-70-8 Do.
Borax
Boric acid
2-Bromo-2-nitro-1, 3-propanediol (CAS Reg. No. 52-51-7) For use only as an antibacterial preservative.
Butanedioic acid, sulfo-1,4-di-(C9-C11 alkyl) ester, ammonium salt (also known as butanedioic acid, sulfo-1,4-diisodecyl ester, ammonium salt [CAS Reg. No. 144093-88-9]). For use as a surface active agent in adhesives.
1,3-Butanediol
1,4-Butanediol
1,4-Butanediol modified with adipic acid
Butoxy polyethylene polyproplyene glycol (molecular weight 900-4,200)
Butyl acetate
Butyl acetyl ricinoleate
Butyl alcohol
Butylated reaction product of p-cresol and dicyclopentadiene As identified in § 178.2010(b) of this chapter.
Butylated, styrenated cresols identified in § 178.2010(b) of this chapter
Butyl benzoate
Butyl benzyl phthalate
Butyldecyl phthalate
1,3-Butylene glycoldiglycolic acid copolymer
tert-Butyl hydroperoxide
4,4′-Butylidenebis(6-tert-butyl-m-cresol)
Butyl lactate
Butyloctyl phthalate
p-tert-Butylphenyl salicylate
Butyl phthalate butyl glycolate
p-tert-Butylpyrocatechol For use only as polymerization-control agent.
Butyl ricinoleate
Butyl rubber polymer
Butyl stearate
Butyl titanate, polymerized
Butyraldehyde
Calcium ethyl acetoacetate
Calcium nitrate
Calcium metasilicate
Camphor
Camphor fatty acid esters
Candelilla wax
epsilon-Caprolactam-(ethylene-ethyl acrylate) graft polymer
Carbon black, channel process
Carbon disulfide-1,1′-methylenedipiperidine reaction product
Carbon tetrachloride
Carboxymethylcellulose
Castor oil, polyoxyethylated (4-84 moles ethylene oxide)
Cellulose acetate butyrate
Cellulose acetate propionate
Ceresin wax (ozocerite)
Cetyl alcohol
Chloracetamide
Chloral hydrate
Chlorinated liquid n-paraffins with chain lengths of C10-C17, containing 40-70 percent chlorine by weight
Code of Federal Regulations 159
Chlorinated pyridine mixture with active ingredients consisting of 2,3,5,6-tetrachloro-4-(methylsulfonyl) pyridine, 2,3,5,6-tetrachloro-4-(methylsulfinyl) pyridine and pentachloropyridine For use as preservative only.
Chlorinated rubber polymer (natural rubber polymer containing approximately 67 percent chlorine)
1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride For use as preservative only.
Chlorobenzene
4-Chloro-3,5-dimethylphenol (p-chloro-m-xylenol) For use as preservative only.
4-Chloro-3-methylphenol Do.
5-Chloro-2-methyl-4-isothiazolin-3-one (CAS Reg. No. 26172-55-4) and 2-methyl-4-isothiazolin-3-one (CAS Reg. No. 2682-20-4) mixture at a ratio of 3 parts to 1 part, manufactured from methyl-3-mercaptopropionate (CAS Reg. No. 2935-90-2). The mixture may contain magnesium nitrate (CAS Reg. No. 10377-60-3) at a concentration equivalent to the isothiazolone active ingredients (weight/weight) For use only as an antimicrobial agent in polymer latex emulsions.
Chloroform
Chloroprene
Chromium caseinate
Chromium nitrate
Chromium potassium sulfate
Cobaltous acetate
Coconut fatty acid amine salt of tetrachlorophenol For use as preservative only.
Copal
Copper 8-quinolinolate For use as preservative only.
Coumarone-indene resin
Cresyl diphenyl phosphate
Cumene hydroperoxide
Cyanoguanidine
Cyclized rubber as identified in § 176.170(b)(2) of this chapter
Cyclohexane
1,4-Cyclohexanedimethanoldibenzoate (CAS Reg. No. 35541-81-2)
Cyclohexanol
Cyclohexanone resin
Cyclohexanone-formaldehyde condensate
N-Cyclohexyl p-toluene sulfonamide
5-Cyclopentadienyl)-(η6-isopropylbenzene)iron(II) hexafluorophosphate (CAS Reg. No. 32760-80-8) For use only as a photoinitiator.
Damar
Defoaming agents as described in § 176.210 of this chapter
Dehydroacetic acid
Diacetone alcohol
Diacetyl peroxide
N,N′-Dialkoyl-4,4′-diaminodiphenylmethane mixtures where; the alkoyl groups are derived from marine fatty acids (C12-C24)
2,5-Di-tert-amylhydroquinone
Diamines derived from dimerized vegetable oil acids
Diaryl-p-phenylenediamine, where the aryl group may be phenyl, tolyl, or xylyl
1,2-Dibromo-2,4-dicyanobutane (CAS Registry No. 3569-65-7) For use as a preservative only.
2,2-Dibromo-3-nitrilopropionamide (CAS Reg. No. 10222-01-2). For use as a preservative only.
Di(butoxyethyl) phthalate
2,5-Di-tert-butylhydroquinone
Dibutyl maleate
2,6-Di-tert-butyl-4-methylphenol For use as preservative only.
Di(C7, C9-alkyl)adipate
Dibutyl phthalate
Dibutyl sebacate
Dibutyltin dilaurate for use only as a catalyst for polyurethane resins
1,2-Dichloroethylene (mixed isomers)
Dicumyl peroxide
Dicyclohexyl phthalate
Diethanolamine
Diethanolamine condensed with animal or vegetable fatty acids
Diethylamine
Diethylene glycol
Diethylene glycol adipic acid copolymer
Diethylene glycol dibenzoate
Diethylene glycol hydrogenated tallowate monoester
Diethylene glycol laurate
Diethylene glycol monobutyl ether
Diethylene glycol monobutyl ether acetate
Diethylene glycol monoethyl ether
Code of Federal Regulations 160
Diethylene glycol monoethyl ether acetate
Diethylene glycol monomethyl ether
Diethylene glycol monooleate
Diethylene glycol monophenyl ether
Diethylene glycol copolymer of adipic acid and phthalic anhydride
Di(2-ethylhexyl) adipate
Di(2-ethylhexyl)hexahydrophthalate
Di(2-ethylhexyl)phthalate
Diethyl oxalate
Diethyl phthalate
Dihexyl phthalate
Dihydroabietylphthalate
Di(2-hydroxy-5-tert-butylphenyl) sulfide
2,2′-Dihydroxy-5,5′-dichlorodiphenylmethane (dichlorophene)
4,5-Dihydroxy-2-imidazolidinone
4-(Diiodomethylsulfonyl) toluene CA Registry No.: 20018-09-01 For use as an antifungal preservative only.
Diisobutyl adipate
Diisobutyl ketone
Diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride
Diisobutyl phthalate
Diisodecyl adipate
Diisodecyl phthalate
Diisooctyl phthalate
Diisopropylbenzene hydroperoxide
N,N-Dimethylcyclohexylamine dibutyldithiocarbamate
Dimethyl formamide
Dimethyl hexynol
2,2-Dimethyl-1,3-propanediol dibenzoate
Dimethyl octynediol
N-(1,1-dimethyl-3-oxobutyl) acrylamide
Dimethyl phthalate
3,5-Dimethyl-1,3,5,2H-tetrahydrothiadiazine-2-thione For use as preservative only.
Di-β-naphthyl-p-phenylenediamine
4,6-Dinonyl-o-cresol
Dinonylphenol
Di-n-octyldecyl adipate
Dioctyldiphenylamine
Dioctylphthalate
Dioctylsebacate
Dioxane
Dipentaerythritol pentastearate
Dipentamethylene-thiuram-tetrasulfide
Dipentene
Dipentene resins
Dipentene-beta-pinene-styrene resins
Dipentene-styrene resin (CAS Registry No. 64536-06-7)
Diphenyl-2-ethylhexyl phosphate
Diphenyl, hydrogen ated
N,N′-Diphenyl-p-phenylenediamine
Diphenyl phthalate
1,3-Diphenyl-2-thiourea
Dipropylene glycol
Dipropylene glycol dibenzoate
Dipropylene glycol monomethyl ether
Dipropylene glycol copolymer of adipic acid and phthalic anhydride
Disodium cyanodithioimidocarbonate
Disodium 4-isodecyl sulfosuccinate (CAS Reg. No. 37294-49-8)
N,N′-Distearoylethylenediamine
Distearyl thiodipropionate
3,5-Di-tert-butyl-4-hydroxyhydrocinnamic acid triester with 1,3,5-tris(2-hydroxyethyl)-s-triazine-2,4,6(1H, 3H, 5H)-trione For use as antioxidant only.
4,4′-Dithiodimorpholine
n-Dodecylmercaptan
tert-Dodecylmercaptan
Dodecylphenoxybenzene-disulfonic acid and/or its calcium, magnesium, and sodium salts
Elemi gum
Epichlorohydrin-4,4′-isopropylidenediphenol resin
Epichlorohydrin-4,4′-sec-butylidenediphenol resin
Epichlorohydrin-4,4′-isopropylidene-di-o-cresol resin
Epichlorohydrin-phenolformaldehyde resin
Erucamide (erucylamide)
Ethanolamine
Ethoxylated primary linear alcohols of greater than 10 percent ethylene oxide by weight having molecular weights of 390 to 7,000 (CAS Reg. No. 97953-22-5)
Code of Federal Regulations 161
Ethoxypropanol butyl ether
Ethyl alcohol (ethanol)
5-Ethyl-1,3-diglycidyl-5-methylhydantoin (CAS Reg. No. 15336-82-0)
Ethylene-acrylic acid-carbon monoxide copolymer (CAS Reg. No. 97756-27-9)
Ethylene-acrylic acid copolymer, partial sodium salt containing no more than 20 percent acrylic acid by weight, and no more than 16 percent of the acrylic acid as the sodium salt (CAS Reg. No. 25750-82-7)
Ethylenediamine
Ethylenediaminetetra-acetic acid, calcium, ferric, potassium, or sodium salts, single or mixed
Ethylene dichloride
Ethylene glycol
Ethylene glycol monobutyl ether
Ethylene glycol monobutyl ether acetate
Ethylene glycol monoethyl ether
Ethylene glycol monoethyl ether acetate
Ethylene glycol monoethyl ether ricinoleate
Ethylene glycol monomethyl ether
Ethylene glycol monophenyl ether
Ethylene-carbon monoxide copolymer (CAS Reg. No. 25052-62-4) containing not more than 30 weight percent of the units derived from carbon monoxide
Ethylene-maleic anhydride copolymer, ammonium or potassium salt
Ethylene-methacrylic acid copolymer partial salts: Ammonium, calcium, magnesium, sodium, and/or zinc
Ethylene-methacrylic acid-vinyl acetate copolymer partial salts: Ammonium, calcium, magnesium, sodium, and/or zinc
Ethylene-octene-1 copolymers containing not less than 70 weight percent ethylene (CAS Reg. No. 26221-73-8)
Ethylene-propylene-dicyclopentadiene copolymer rubber
Ethylene, propylene, 1,4-hexadiene and 2,5-norbornadiene tetrapolymer
Ethylene-vinyl acetate carbon monoxide terpolymer (CAS Registry No. 26337-35-9) containing not more than 15 weight percent of units derived from carbon monoxide
2,2′-Ethylidenebis (4,6-di-tert-butylphenol) (CAS Reg. No. 35958-30-6)
Ethyl-p-hydroxybenzoate For use as preservative only.
Ethyl hydroxyethylcellulose
Ethyl lactate
2,2′-Ethylidenebis(4,6-di-tert-butylphenyl)fluorophosphonite (CAS Reg. No. 118337-09-0) For use as an antioxidant and/or stabilizer only.
Ethyl phthalyl ethyl glycolate
Ethyl-p-toluene sulfonamide
Fats and oils derived from animal or vegetable sources, and the hydrogenated, sulfated, or sulfonated forms of such fats and oils
Fatty acids derived from animal or vegetable fats and oils; and salts of such acids, single or mixed, as follows:
Aluminum
Ammonium
Calcium
Magnesium
Potassium
Sodium
Zinc
Ferric chloride
Fluosilicic acid (hydrofluosilicic acid) For use only as bonding agent for aluminum foil, stabilizer, or preservative. Total fluoride from all sources not to exceed 1 percent by weight of the finished adhesive.
Formaldehyde
Formaldehyde o- and p-toluene sulfonamide
Formamide
Fumaratochromium (III) nitrate
Furfural
Furfuryl alcohol
Fumaric acid
gamma-Aminopropyltrimethoxysilane (CAS Reg. No. 13822-56-5)
Glutaraldehyde
Glycerides, di- and monoesters
Glycerol polyoxypropylene triol, minimum average molecular weight 250 (CAS Reg. No. 25791-96-2) For use only in the preparation of polyester and polyurethane resins in adhesives.
Glyceryl borate (glycol boriborate resin)
Code of Federal Regulations 162
Glyceryl ester of damar, copal, elemi, and sandarac
Glyceryl monobutyl ricinoleate
Glyceryl monohydroxy stearate
Glyceryl monohydroxy tallowate
Glyceryl polyoxypropylene triol (average molecular weight 1,000)
Glyceryl tribenzoate
Glycol diacetate
Glyoxal
Heptane
Hexamethylenetetramine
Hexane
Hexanetriols
Hexylene glycol
Hydroabietyl alcohol
Hydrocarbon resins (produced by polymerization of mixtures of mono- and di-unsaturated hydrocarbons of the aliphatic, alicyclic, and monobenzenoid type derived both from cracked petroleum and terpene stocks) (CAS Reg. No. 68239-99-6)
Hydrocarbon resins (produced by the polymerization of styrene and alpha-methyl styrene), hydrogenated (CAS Reg. No. 68441-37-2)
Hydrofluoric acid For use only as bonding agent for aluminum foil, stabilizer, or preservative. Total fluoride from all sources not to exceed 1 percent by weight of the finished adhesive.
Hydrogen peroxide
Hydrogenated dipentene resin (CAS Reg. No. 106168-39-2)
Hydrogenated dipentene-styrene copolymer resin (CAS Reg. No. 106168-36-9)
Hydrogenated-beta-pinene-alpha-pinene-dipentene copolymer resin (CAS Reg. No. 106168-37-0)
a-Hydro-omega-hydroxypoly-(oxytetramethylene) For use only in the preparation of polyurethane resins.
Hydroquinone
Hydroquinone monobenzyl ether
Hydroquinone monoethyl ether
2(2′-Hydroxy-3′,5′ di-tert-amylphenyl) benzotriazole
Hydroxyacetic acid
7-Hydroxycoumarin
Hydroxyethylcellulose
2-Hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone(CAS Reg. No. 106797-53-9) For use only as a photoinitiator at a level not to exceed 5 percent by weight of the adhesive.
1-(2-Hydroxyethyl)-1-(4-chlorobutyl)-2 alkyl (C6-C17) imidazolinium chloride
Hydroxyethyldiethylenetriamine
β-Hydroxyethyl pyridinium 2-mercaptobenzothiazol
Hydroxyethyl starch
Hydroxyethylurea
Hydroxylamine sulfate
5-Hydroxymethoxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane, 5-hydroxymethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane, and 5-hydroxypoly-[methyleneoxy]methyl-1-aza-3,7-dioxabicyclo[3.3.0] octane mixture For use only as an antibacterial preservative.
Hydroxypropyl methylcellulose
2-(Hydroxymethyl)-2-methyl-1,3-propanediol tribenzoate
2-Imidazolidinone
3-Iodo-2-propynyl-N-butyl carbamate (CAS Reg. No. 55406-53-6) For use only as an antifungal preservative.
Iodoform For use only as polymerization-control agent.
Isoascorbic acid
Isobutyl alcohol (isobutanol)
Isobutylene-isoprene copolymer
Isodecyl benzoate (CAS Reg. No. 131298-44-7)
Isophorone
Isopropanolamine (mono-, di-, tri-)
Isopropyl acetate
Isopropyl alcohol (isopropanol)
Isopropyl-m- and p-cresol (thymol derived)
4,4′-Isopropylidenediphenol
4,4′-Isopropylidenediphenol, polybutylated mixture For use as preservative only.
Isopropyl peroxydicarbonate
p-Isopropoxy diphenylamine
4,4′-Isopropylidene-bis(p-phenyleneoxy)-di-2-propanol
Itaconic acid
Japan wax
Kerosene
Lauroyl peroxide
Code of Federal Regulations 163
Lauroyl sulfate salts:
Ammonium
Magnesium
Potassium
Sodium
Lauryl alcohol
Lauryl pyridinium 5-chloro-2-mercaptobenzothiazole
Lignin calcium sulfonate
Lignin sodium sulfonate
Linoleamide (linoleic acid amide)
Magnesium fluoride For use only as bonding agent for aluminum foil, stabilizer, or preservative. Total fluoride from all sources not to exceed 1 percent by weight of the finished adhesives.
Magnesium glycerophosphate
Maleic acid
Maleic anhydride-diisobutylene copolymer, ammonium or sodium salt
Manganese acetate
Marine oil fatty acid soaps, hydrogenated
Melamine
Melamine-formaldehyde copolymer
2-Mercaptobenzothiazole
2-Mercaptobenzothiazole and dimethyl dithiocarbamic acid mixture, sodium salt For use as preservative only.
2-Mercaptobenzothiazole, sodium or zinc salt For use as preservative only.
Methacrylate-chromic chloride complex,